Publicerat: 2021-02-26 08:17:14

MarketWire om Curasight A/S: Article from Phase II study in prostate cancer now published in the March issue of Journal of Nuclear Medicine and highlighted as best clinical investigation article

The phase II studyThe phase II study aimed to evaluate the correlation between uptake on uPAR-PET with [68]Ga-NOTA-AE105 (uTRACE[®]) and Gleason Score in prostate cancer patients undergoing prostate biopsy. SUV[*)] measurements from uPAR PET in primary tumors as delineated by mpMRI showed a significant correlation with Gleason score, and tumor SUVmax was able to discriminate between low-risk and intermediate-risk Gleason score profiles with high diagnostic accuracy. Consequently, uPAR PET/MRI could be a promising method for non-invasive prostate cancer evaluation, which may in the future potentially reduce the need for repeated biopsies, e.g. in active surveillance.About the Journal of Nuclear MedicineThe Journal of Nuclear Medicine is the official publication of the Society for Nuclear Medicine and Molecular Imaging and the highest-ranked journal within nuclear medicine based on the number of citations (impact factor)."We are excited not only that the study from Rigshospitalet has been published in the March issue of Journal of Nuclear Medicine but in particular that it has been selected as the best clinical investigation article. This underscores the quality and impact of the study. Furthermore, and as previously communicated, the study has demonstrated a first proof-of-concept for the idea of using uPAR-PET as a non-invasive measure of cancer aggressiveness in prostate cancer. We believe this supports the potential of using imaging for saving some of the biopsies currently taken. Curasight will take this information into consideration when planning the optimal design of a future Curasight sponsored phase III study in prostate cancer." says CEO Ulrich Krasilnikoff.*) Standardized uptake value (SUV) is a measure of PET tracer concentration. SUVmax is a measure of the maximal value of SUV within a certain region, e.g. within the volume of a tumor. Gleason score is a grading system of prostate cancer aggressiveness based on pathological evaluation of tissue from the tumor.Curasight

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